Genetic predisposition to ductal carcinoma in situ of the breast

C Petridis; MN Brook; V Shah; K Kohut; P Gorman; M Caneppele; D Levi; E Papouli; N Orr; A Cox; SS Cross; I dos-Santos-Silva; J Peto; A Swerdlow; MJ Schoemaker; MK Bolla; Q Wang; J Dennis; K Michailidou; J Benitez; A González-Neira; DC Tessier; D Vincent; J Li; J Figueroa; V Kristensen; AL Borresen-Dale; P Soucy; J Simard; RL Milne; GG Giles; S Margolin; A Lindblom; T Brüning; H Brauch; MC Southey; JL Hopper; T Dörk; NV Bogdanova; M Kabisch; U Hamann; RK Schmutzler; A Meindl; H Brenner; V Arndt; R Winqvist; K Pylkäs; PA Fasching; MW Beckmann; J Lubinski; A Jakubowska; AM Mulligan; IL Andrulis; RAEM Tollenaar; P Devilee; L Le Marchand; CA Haiman; A Mannermaa; VM Kosma; P Radice; P Peterlongo; F Marme; B Burwinkel; CHM van Deurzen; A Hollestelle; N Miller; MJ Kerin; D Lambrechts; G Floris; J Wesseling; H Flyger; SE Bojesen; S Yao; CB Ambrosone; G Chenevix-Trench; T Truong; P Guénel; A Rudolph; J Chang-Claude; H Nevanlinna; C Blomqvist; K Czene; JS Brand; JE Olson; FJ Couch; AM Dunning; P Hall; DF Easton; PDP Pharoah; SE Pinder; MK Schmidt; I Tomlinson; R Roylance; M García-Closas; EJ Sawyer

Journal article

Genetic predisposition to ductal carcinoma in situ of the breast

C Petridis, MN Brook, V Shah, K Kohut, P Gorman, M Caneppele, D Levi, E Papouli, N Orr, A Cox, SS Cross, I dos-Santos-Silva, J Peto, A Swerdlow, MJ Schoemaker, MK Bolla, Q Wang, J Dennis, K Michailidou, J Benitez Show all

Breast Cancer Research | Published : 2016

DOI: 10.1186/s13058-016-0675-7

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Abstract

Background: Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci. Methods: To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip. Results: Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same ..

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